Survey of EPA facilities for solar thermal energy applications

A study was done to assess the feasibility of applying solar thermal energy systems to EPA facilities. A survey was conducted to determine those EPA facilities where solar energy could best be used. These systems were optimized for each specific application and the system/facility combinations were ranked on the basis of greatest cost effectiveness

Low-cost point-focus solar concentrator, phase 1

The results of the preliminary design study for the low cost point focus solar concentrator (LCPFSC) development program are presented. A summary description of the preliminary design is given. The design philosophy used to achieve a cost effective design for mass production is described. The concentrator meets all design requirements specified and is based on practical design solutions in every possible way

The Time Machine: Leisure Science (Fiction) and Futurology

There is a long, underlying presence of futurology—attempts to predict the future based on current or past events—throughout much of the leisure literature. On the occasion of the 40th anniversary of Leisure Sciences, I build on the work of futures scholars (e.g., Adam, 2008; Harrison, 2015) to explore how past ideas about the future have shaped the present. I revisit H. G. Wells's (1895) classic science fiction novel The Time Machine in view of recent trends and recurring debates (e.g., cybernation, (un)employment, the “leisure society,” and Universal Basic Income) that are (or were) forecast to shape the future. Throughout, I argue that the ways that leisure scholars envision the future have significant impact on the actions of the field and its practitioners today

An anatomic gene expression atlas of the adult mouse brain

Studying gene expression provides a powerful means of understanding structure-function relationships in the nervous system. The availability of genome-scale in situ hybridization datasets enables new possibilities for understanding brain organization based on gene expression patterns. The Anatomic Gene Expression Atlas (AGEA) is a new relational atlas revealing the genetic architecture of the adult C57Bl/6J mouse brain based on spatial correlations across expression data for thousands of genes in the Allen Brain Atlas (ABA). The AGEA includes three discovery tools for examining neuroanatomical relationships and boundaries: (1) three-dimensional expression-based correlation maps, (2) a hierarchical transcriptome-based parcellation of the brain and (3) a facility to retrieve from the ABA specific genes showing enriched expression in local correlated domains. The utility of this atlas is illustrated by analysis of genetic organization in the thalamus, striatum and cerebral cortex. The AGEA is a publicly accessible online computational tool integrated with the ABA (http://mouse.brain-map.org/agea)

CAR-associated vesicular transport of an adenovirus in motor neuron axons.

Axonal transport is responsible for the movement of signals and cargo between nerve termini and cell bodies. Pathogens also exploit this pathway to enter and exit the central nervous system. In this study, we characterised the binding, endocytosis and axonal transport of an adenovirus (CAV-2) that preferentially infects neurons. Using biochemical, cell biology, genetic, ultrastructural and live-cell imaging approaches, we show that interaction with the neuronal membrane correlates with coxsackievirus and adenovirus receptor (CAR) surface expression, followed by endocytosis involving clathrin. In axons, long-range CAV-2 motility was bidirectional with a bias for retrograde transport in nonacidic Rab7-positive organelles. Unexpectedly, we found that CAR was associated with CAV-2 vesicles that also transported cargo as functionally distinct as tetanus toxin, neurotrophins, and their receptors. These results suggest that a single axonal transport carrier is capable of transporting functionally distinct cargoes that target different membrane compartments in the soma. We propose that CAV-2 transport is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis

Role of Conformation in Musculoskeletal Problems in the Racing Thoroughbred and Racing Quarter Horse (21-Nov-2003)

Abstract Using a computer-based digitized photographic method of objective analysis of conformation, certain conformation variables that affect the incidence of musculoskeletal problems in the racing Thoroughbred and Quarter horse have been identified